The oral drug delivery systems have evolved from simple pills to engineered systems.

The modified drug systems are able to navigate the GIT hindrances.

The conventional tablets and capsules often operate on a trial-and-error mechanism.

The advanced oral drug delivery consists of targeted delivery systems, which offer fewer side effects and better compliance.

Aprazer Healthcare – The Gastroenterology Drug Manufacturer 

Focused on new drug delivery systems, Aprazer Healthcare manufactures advanced formulations.

From controlled release formulations to gastro-retentive medications, Aprazer Healthcare is a name in pharmaceutical manufacturing.

We manufacture the advanced formulations-

Gastroprotective acid reducers – Proton pump inhibitors

Gastroselective antibiotic – Rifaxigem 400 tablets

How do medicines travel in the GIT tract? Understanding the hostile environment

The drug is absorbed through the gastrointestinal tract at multiple sites.

The GIT tract consists of the stomach, intestine, and colon. Each has a different pH and microbiota.

The absorption of the drug in the GIT is hindered by various factors –

 PH conditions – 

The acidic PH degrades many drugs, leading to irritation or sometimes low solubility.

• Stomach PH is acidic
• Intestinal PH is neutral
• Colon PH is alkaline

Digestive enzymes –The proteolytic enzymes degrade the drug.

It reduces systemic absorption.

Thick mucus – the mucosal layer traps the drug particles. It inhibits the drug from reaching the internal layer for absorption.

Tight epithelial junctions – The tight junctions between the cells prevent the passage of large molecules or hydrophilic drugs.

What are the targeted Systems for increased Oral Drug Absorption in the Gastrointestinal Tract? 

PH responsive systems – 

It is the coating of the drug molecule to dissolve at specific pH levels.

Polymers like Eudragit, etc.

It is widely used for targeted drug delivery in the intestine, the ileum, or the colon.

These bypass the low acid in the stomach.

Mucus penetrating/mucoadhesives – 

Mucosadhesive polymers like chitosan/ carbopol adhere to the mucus layer.

It increases stay time and drug release.

Mucus-penetrating nanoparticles cross the mucosal barrier.

These reach the underlying epithelial layer for absorption.

Microbiome-activated systems- 

They are microbial-triggered systems; the coating layer disintegrates when targeted by a specific enzyme or the colon bacteria.

Nano-carriers- The drug coating consists of lipid-soluble carriers or polymeric carriers for controlled drug release.

These are used to increase –

• Drug loading capacity
• To increase solubility
• Prevent PH degradation

Gastroretentive systems – 

In order to prolong the gastric stay of the drugs, gastro-retentive drug delivery systems are adopted.

These are widely used for drugs that have –

• Narrow- absorption in the upper GIT tract
• Local action
• To increase the solubility of the drug in the stomach

It includes –

• Floating systems – they float in the stomach, increasing the stay in the stomach.
• High-density systems- they sink in the gastric fluid, prolong its stay.
• Swelling systems – they swell up, preventing them from rapidly passing through the pyloric sphincter.

Conclusion – 

The modern drug delivery system has shifted from merely releasing the API to better absorption, targeted action, and fewer side effects.

Aprazer Healthcare is the leading drug manufacturer, investing in research and drug development.

We aim to improve patient outcomes by manufacturing advanced treatment drugs and dosage forms.

It is not the condition that the body does not respond to antibiotics.

It is caused when the bacteria do not respond to antibiotics.

It is a global health challenge.

The unselective and frequent use of antibiotics has emerged as a threat to effective treatment.

It leads to treatment failure and the spread of the disease.

Ultimately, developing resistance to the drug.

Antimicrobial Resistance- Why and How?

The bacteria or the microbes change their structure.

It gets adapted to the antibiotics.

The medicine becomes ineffective.

It is not able to treat bacterial infection.

Antimicrobial resistance is caused by – 

Over prescription/self-medication – 

The frequent use of antibiotics.

The self-medication causes an overuse of antibiotics.

Without identifying the strain, these are used over the counter to treat simple flu and viral infections.

Antibiotics in viral infections – 

Antibiotics can’t be used for viral diseases.

It cannot cure viral infections.

It causes unnecessary exposure. It provides an opportunity for the bacteria to develop resistance.

Incomplete treatment – It leaves the viable bacteria.

The remaining microbes lead to the development of resistance.

Overuse of antibiotics – 

The use of pesticides in agricultural processes.

The antibiotics in cow milk.

It causes an accumulation of antibiotic content in the body.

It increases the risk of developing resistance.

Insanity and unhygienic – 

The contaminated water and surface.

It is the breeding area for resistant bacteria.

Incorrect use of antibiotics – 

Not using a specific antibiotic for the particular strain.

It increases the risk of resistance.

How does antimicrobial resistance lead to treatment failure?

The development of resistance to the bacteria renders the following effects-

It leads to inefficacy of the treatment.

It causes the spread of bacterial infection.

It leads to the use of stronger antibiotics for infections.

It advances the disease to chronic and complex conditions.

Aprazer Healthcare – Manufacturing a range of antimicrobial drugs

Aprazer Healthcare is leading pharmaceutical company.

It is the largest drug manufacturer.

We continue to invest in research and drug development.

We have robust R&D facilities.

Aprazer Healthcare is at the forefront of developing new drug molecules.

Our antimicrobial range consists of –

• Antibiotics
• Antibiotic injectable
• Antiviral
• Anthelmintic

Cancer medication side effects vary from one another.

It can range from mild to severe side effects, depending on several factors-

• Type of therapy
• Overall health
• Medication dose
• Delivery method
• Type of combinations

As the leading pharmaceutical company, Aprazer Healthcare manufactures a range of anticancer drugs.

With continuous drug discovery and development, we are focused on developing innovative cancer treatments.

We have WHO-GMP-approved manufacturing facilities.

We manufacture a complete range of oncology orals and oncology injectables.

The common side effects include –

Cancer drugs affect normal body cells. It alters the body’s functions and metabolism.

Bone marrow suppression – 

The cancer drugs act upon the rapidly dividing cells.

The bone marrow produces the blood cells in huge numbers every day.

The cancer drugs attack the stem cells.

It reduces the blood count.

It causes 3 effects –

• Neutropenia –

It is a condition with a drop in white blood cells.

This weakens the immune system.

This reduces body’s ability to fight infections.

This increases the risk of infections.

• Anemia – The decrease in red blood cells causes weakness.

These carry oxygen in the body.

The healthy cells get deprived of oxygen.

• Thrombocytopenia – 

It is caused by the fall in platelet count.

This causes bleeding upon bruises or injury.

It inhibits the clotting of the blood.

Gastrointestinal side effects 

The cancer medicines destroy the gastrointestinal lining.

It causes epithelial cell damage.

It leads to gut dysbiosis and inflammation.

It can cause –

• Nausea
• Diarrhea
• Vomiting
• Mouth ulcers
• Loss of appetite
• Taste changes
• changes in bowel habits

Systemic and neurological side effects 

Weakness- 

Extreme tiredness due to anemia.

It leads to continuous exhaustion due to systemic inflammation.

Lack of energy for cell repair and metabolism.

Liver /kidney damage- 

The toxic drug metabolites are cleared through the liver /kidney.

It leads to toxic burdening of the organs.

Peripheral neuropathy 

The cancer drugs damage the peripheral nerves.

It damages the neurons.

It leads to –

• Numbness
• burning pain
• Hypersensitivity
• Balance issues
• Orthostatic hypotension

Hair loss- 

The cancer drugs affect the keratinocytes in the hair follicles.

It resists hair growth.

The hair shaft breaks off and falls.

Skin /nail changes –

The chemo drugs inhibit the oil gland secretions.

It leads to depletion of moisture.

It causes-

• Dryness
• Itching
• Rashes
• Pruritus
• Photosensitivity

Infertility- 

The cancer drugs reach the gonads.

They stop formation of new blood vessels.

It reduces the blood supply to the reproductive organs.

It also kills the sperm producing cells or the egg cells.

Chemo brain 

Cancer drugs affect healthy tissues.

It releases a large amount of pro-inflammatory kinases.

This activates the brain’s immune cells.

Certain drugs cross the blood-brain barrier.

This damages the wall of the blood vessels.

It also damages the neural stem cells.

The axons are damaged, inhibiting electrical signals.

Are these side effects manageable?

These side effects often resolve in a few months after the completion of the treatment.

• Plan daily activities.
• Exercise
• Reduce stress
• Focus on diet
• Apply moisture for skin changes
• Use scalp cooling
• increase hydration
• Take an antiemetic as given by the doctor

Note – In cases of severe symptoms, always visit an oncologist.

Avoid any medicines on your own.

Non–calorie sweeteners are extensively used in weight loss regimes.

Often, diabetics, to satisfy their sweet tooth, rely on artificial sweeteners.

Artificial sweeteners are usually found in all packaged foods.

Not only adults, but children are also using it excessively in the form of processed food items.

It is one of the major reasons for obesity disease, type -2 diabetes, increasing in children.

It becomes important to be aware of the lifestyle changes that adversely affect health.

At Aprazer Healthcare (pharmaceutical manufacturer), we believe that healthcare extends beyond medication and diagnosis.

Proactive measures play a significant role in disease prevention and management.

Leveraging the cutting –edge technology, we are focused on manufacturing advanced medicines focused on lifestyle disorders.

We are the leading life –saving medicine manufacturer and exporter from India.

Commonly used sweeteners – 

Sweeteners are used to prepare food items.

It includes a wide range, from bakery food to beverages.

• Aspartame
• Sucralose
• Saccharin
• Acesulfame Potassium
• High fructose corn syrup

Where are artificial sweeteners used? 

Marketed food items- 

These are widely used as these sweeteners are 100 times sweeter than sugar.

They offer a cost-effective option.

They are used in small amounts compared to sugar.

They are lower in calories.

These are heat-stable and have longer shelf –life.

Weight management – The artificial sweeteners are calorie-deficient products.

They bring the sweet taste without fat gain.

Diabetes – They do not bring an immediate sugar spike.

It is used for the sweet taste.

Artificial sweeteners are an unhealthy choice. Why? 

When used for the short term, it may be a healthy option.

Long-term use leads to several repercussions.

It increases the risk of-

• Type -2 diabetes
• Hypertension
• Obesity
• Heart problems
• Stroke
• Mood changes
• Depression
• Anxiety

Metabolic deregulation – 

It leads to cravings.

It causes overeating.

It causes insulin resistance.

It increases hunger.

Gut issues – 

They change the gut microbiota.

This leads to depletion of healthy bacteria.

It leads to inflammation in the gut.

It causes bloating and diarrhea.

It can cause IBS.

Cardiovascular issues- 

Many sweeteners increase the risk of stroke, blockage, and heart attack.

They increase the platelet formation.

It thickens the blood.

It disrupts the flow of the blood.

Neurological issue- 

They cause inflammation in the brain and gut. 

It affects the neurotransmitters.

It leads to –

• Mood swings
• Anxiety
• Depression

They release free radicals, damaging brain cells.

Understanding the additive nature of artificial sweeteners- 

Excessive sugar use may increase its liking and craving.

It releases dopamine in the brain.

It brings a hike in sugar and the neurotransmitter.

It causes a state of temporary happiness.

After a temporary effect, sugar comes down.

It leads to a craving.

The unnatural sweeteners are much sweeter than sugar.

It leads to the release of a large amount of dopamine in the brain.

Sugar addiction is real in children.

Children unknowingly fall prey to the vicious circle of sugar addiction.

It is available in all the marketed food items.

The symptoms that the child is regularly eating processed items include-

• Aggression
• Hyperactivity
• Anxiety
• brain fog

Moderation is important. The diet should be focused on using natural sugars.

India has a rapid rise in oral cancer cases. It holds a significant share in the global burden of oral cancer.

90 percent of oral cancer is diagnosed in regular tobacco users.

The traditional use of betel quid, gutkha, and betel nut as a stimulant raises concern.

Aggressively marketed and advertised, it is widely used in children and adults alike.

What is oral cancer? 

It is the cancer of the cells in the mouth. It involves the cancer of the –

Oral cavity, lips, gums, tongue, inner lining of cheeks, upper roof of the mouth, and lower surface of the mouth.

Oral cancer symptoms – 

• persistent ulcers in the mouth
• Pain in the mouth
• A mass or lump in the mouth
• Patches in the mouth
• Inability to swallow
• Weight loss
• Bad breath
• Loose teeth
• A persistent sore throat
• A lump or thickening in the lip
• Pain in the ear
• Unusual bleeding

What increases oral cancer risk?

• Use of tobacco – Tobacco contains cancer-causing elements that increase the risk of cancer.
• Alcohol use –Alcohol increases the irritation of the mouth lining and the risk of cancer.
• Exposure to the sun– UV radiation causes cancer and increases the risk of lip cancer.

It is the cancer that affects the squamous cells of the lips.

• Human papillomavirus –

It harms the inner lining of the mouth. It causes mouth cancer.

It can be transmitted through unsafe sex.

• A weak immune system– An infection or the treatment that lowers body immunity, increases the risk of opportunistic infections, and the risk of cancer. HIV infections / AIDS and other chronic diseases.

Treatment for oral cancers 

• Surgery – It involves the removal of the cancerous part.
• Radiation therapy- The high-intensity radiation is projected on the target tumor externally.

The radiating source can also be placed inside the body.

• Immunotherapy – The drugs increase the immune activity. It identifies and kills cancer cells.
• Targeted therapy – The drugs target the specific cell or the enzymes. It inhibits cancer cell proliferation or growth.

Anticancer Medicines used in Oral Cancer  

• Cycokast (Cisplatin injection ) and Carbokast (Carboplatin injection)
• Docekast (Docetaxel injection ) and Paclikast (Paclitaxel injection )
• Aprahydra (Hydroxyurea injection )
• Capekast  (Capecitabine injection )
• Trexazer (Methotrexate injection )
• 5-Fluorouracil (5-FU)

Can we prevent Oral Cancer?

The use of tobacco and alcohol increases cancer risk notably.

Various modifiable lifestyle risk factors –

• Avoiding tobacco
• Limiting alcohol
• Good oral hygiene
• Healthy diet
• Exercise

Aprazer Healthcare – The Oncology Injectable Manufacturer 

As the largest Indian pharmaceutical company, Aprazer Healthcare is a significant player in the oncology drug manufacturing sector.

We are the top manufacturers and suppliers of anticancer drugs.

We offer a wide range of generic anticancer injections/orals for domestic and international markets.

Using advanced manufacturing techniques for liquid/powder injections, Aprazer Healthcare is the largest oncology injectable manufacturer.

We are a fast-growing pharmaceutical company with a significant share in the oncology drug market, manufacturing affordable medicines.

Changing lifestyle and the rise in diseases has fled the demand for generic medicines.

The emerging economies rely on generic drugs for affordability and availability.

The generic drugs offer cost-effective alternatives with the same clinical outcomes.

The healthcare system is shifting towards precision and targeted therapies.

Pharmaceutical manufacturing is transitioning to develop advanced therapy medicines and complex generics.

Complex generics are generic drugs, manufactured with the latest advancements in novel drug delivery systems, offering a targeted approach.

Aprazer Healthcare – The Generic Drug Manufacturer 

Aprazer Healthcare is at the forefront of manufacturing advanced drugs.

• Complex generics
• Branded generics

Leveraging cutting-edge technology, we manufacture the new treatment drugs.

We specialize in manufacturing –

• Modified release tablets/capsules.
• Pre-filled syringes
• RTU technology injections

We are generic drug manufacturers; we are global exporters of a large range of pharmaceutical products.

What are generic drugs?

Generic drugs are medicines that are brand equivalent.

They have the same therapeutic efficacy, safety, and strength as the branded drugs.

Branded drugs are patent medicines manufactured or invented by the company that owns the patent.

These are developed by extensive research and the drug development process.

The manufacturing company retains the rights to manufacture the drug.

They are higher in cost.

What are complex generics?

These are the brand equivalent drugs that contain complex APIs, formulations, and dosage forms.

The various forms include-

• • Complex dosage forms – Transdermal patches
  • Drug – device combination – Inhalers, Auto-injectors

• Complex API – Peptides, liposomes 

• Modified release mechanisms- controlled release formulations

• Locally acting drugs – creams, ophthalmic preparations, etc.

Challenges in manufacturing complex generics 

The manufacturing of advanced therapy drugs involves both technological and regulatory advancements.

The hurdles faced in manufacturing complex therapeutics include-

Technical complexity – 

Manufacturing complex products requires complex equipment and advanced technology.

It requires multi-step controls and testing compared to standard medicines.

Clinical studies required – The development of a complex system requires human trials compared to a conventional drug system.

Patent hurdles – Manufacturing device combination may include a patent or copyright for the use of a device component or parts.

Undeveloped regulatory standards – The regulatory systems are not developed to approve advanced drugs. It leads to delays and failures.

Scale up and process consistency – scaling up complex manufacturing processes and maintaining consistency add up to the rigor.

The development of complex therapeutics requires high investment costs.

Aprazer Healthcare is the leading manufacturer of complex generics.

With world-class infrastructure, Aprazer Healthcare aligns with the latest technological advancements.

Manufacturing injectables requires a critical process of manufacturing and quality control compared to orals.

The parenteral being injected into the bloodstream needs to be sterile and safe.

Since water is used as a primary solvent, the quality parameters are stringent on the sterility of water.

The sterile manufacturing requires a proper air quality system to prevent cross-contamination.

This emphasizes the necessity of –

Advanced filtration, cleaned rooms, sterilization, and aseptic techniques for the process.

Aprazer Healthcare – Manufacturing the global quality injectables

As a pharmaceutical manufacturer, we are equipped with the latest advanced techniques to ensure sterility and safety of injectable preparations.

We strictly adhere to WHO-GMP standards.

From the manufacturing to the final filling, each step of the process is tested and controlled.

Our quality assurance parameters include –

• Raw material analysis
• In–process monitoring
• Finish product analysis
• Gowning & Personnel Validation

The critical quality attributes for injections- 

• Sterility – free of microorganisms
• Bacterial endotoxins- free of pyrogens
• Free of particulate matter
• PH and Osmolality – Isotonic with the body fluids
• Volume uniformity- the content should be equally dispersed for the intended dosage.
• API potency – Validation of API concentration and potency.

It requires manufacturing attributes as –

• Environmental control, clean rooms –

The manufacturing process must be carried out in clean rooms.

It must prevent contamination.

• Aseptic manufacturing – sterile conditions must be maintained.
• Depyrogenation technique – Adequate glassware or filtration to remove endotoxins.
• Terminal Sterilization – Autoclave /heat treatments
• Continuous monitoring – monitoring the pressure, temperature, errors, and flow of the material.

Finish product testing – 

• Sterility testing
• Endotoxin testing
• Particulate matter analysis
• Container Closure Integrity Testing (CCIT)
• 100% Visual Inspection

How does Aprazer Healthcare ensure adherence to operational criteria?

We are equipped with –

Advanced air filtration 

Grade A (class 100) conditions to control airborne contamination.

• HEPA filters – High-efficiency filters to eliminate particulate matter from the air.
• Laminar air flow system
• Positive pressure differentials to prevent contamination

Purified water systems 

• Double reverse osmosis
• Electrodeionisation
• Continuous loop system and UV treatment

We have an advanced manufacturing unit based on modern features – 

• Walkable false ceilings

• GI –powder-coated panels to prevent dust pockets in the corners.
• Interlocked doors
• Advanced HVAC systems
• Sanitization and disinfection
• Aseptic Process Simulation
• Gowning protocols

Partner with the top –quality injectable manufacturer – 

Aprazer Healthcare is a leading pharmaceutical manufacturer.

We specialize in manufacturing injectables.

We are the leading oncology injectable manufacturer and exporter.

Our portfolio for injectables –

• Critical care injections
• Oncology injections.

These are the two documents that are important to import a pharmaceutical product into the destination country.

It ensures that the product to be imported is safe and efficient to be sold in the desired market.

It gives marketing access to the importers for the product.

The two files contain standard steps to harmonize the quality and safety of the products, opening gateways to countries worldwide.

What is CTD (Common Technical Document)?

It is a set of documents that is submitted to the regulatory authorities.

It consists of applications for the authorization to market the pharmaceutical product.

It is developed by the International Council of Harmonization that a single dossier shall be submitted to different regulatory bodies.

It consists of 5 modules.

Module 1 is specific to the country.

The other module remains the same for all the regions.

• Module 1 – It specifies the local labeling or the prescribing content as per the country.
• Module 2 – It summarizes the quality of the finished product.
• Module 3- It consists of the complete details of chemicals used, quality controls, and manufacturing processes.
• Module 4 – It contains all the non- clinical study reports.
• Module 5 – It includes the clinical study reports.

What is DMF (Drug Master File)?

It is a confidential document.

It is submitted by the manufacturer.

It consists of the manufacturing details of the API, intermediates, and the packaging material.

It consists of –

• Details about the API, its synthesis, and processes.
• Manufacturing facility layout, manufacturing processes used.
• Quality protocols, stability, shelf life, etc.

Why is it required for importers?

Importers need these 2 documents to ensure legal compliance-

• It is required to approve a new product in the market.
• It is proof of quality.
• It ensures the ingredients used are pure, safe, and stable.
• It protects intellectual property rights.
• It streamlines the global entry.
• Verify batch consistency and purity.
•  build trust based on assured quality

Aprazer Healthcare Steadfast Import Approvals

Aprazer Healthcare navigates the regulatory processes without undue delays.

• Submitting dossiers
• Obtaining authorizations.

We maintain stringent quality parameters and standardized manufacturing processes.

By submitting true and unbiased information, we work in the interests of the stakeholders.

Our foundation, built on consistency and reliability, makes us the leading healthcare partners.

We are a leading pharmaceutical exporter to Asia, Africa, and South America.

The growing incidence of CKD highlights the gap in healthcare.

It emphasizes the urgent need for proactive care.

Nearly 10 percent of the population in Asia faces the risk of a kidney disorder.

The inequitable burden exists due to –

• Environmental factors – The insanity conditions, contaminated water, heavy metals, and industrial waste.
• Dietary habits – The traditional practices of eating spicy, salty food.
• Unequal access to healthcare
• Lack of awareness
• Unaffordable treatment

Aprazer Healthcare ambitioned to provide affordable access to healthcare

As a nephrology medicine manufacturer, Aprazer Healthcare manufactures affordable kidney care medicines.

We offer the widest product portfolio in nephrology care-

• Transplant medicines
• Diuretics
• Uric acid medicines
• Blood pressure medicines

We supply nephrology drugs to the Indian and international markets.

We are pharmaceutical manufacturers.

We manufacture a range of lifesaving drugs.

Know what CKD is?

It is a slow process. It is a gradual reduction in renal functions.

The nephrons get damaged. The kidney is not able to perform filtration.

It leads to the build-up of toxins.

It is an irreversible damage.

It exacerbates the co-morbidities like –

• Cardiovascular disorders
• Diabetes
• Hypertension

It causes complications like –

• Anemia
• Heart disease
• bone degeneration
• High blood pressure
• Electrolyte imbalance
• hormonal imbalance
• cognitive side effects

What are the risk factors for CKD?

CKD does not happen immediately; the kidney damage starts very slowly without you even knowing.

• Diabetes
• High blood pressure
• Obesity
• Smoking
• Heart disease
• Kidney stones
• Kidney infections
• Medications
• Genetics
• Growing age
• Renal cell injury

Chronic kidney disorder symptoms – 

• Weakness
• Swelling
• Changes in urination
• Itchy skin
• Muscle cramps
• Trouble sleeping
• High BP

Preventive measures to cut down CKD risk- 

Healthy ways of living –

• Hydration
• Eating low-sugar/salty food
• Regular exercise
• Limiting alcohol /smoke
• Using painkillers wisely

Managing the chronic diseases that damage the kidneys.

Awareness is a proactive measure towards prevention

CKD has no symptoms in the early stages.

Regular screening becomes important for people at high risk.

Elderly and those with diabetes or BP should necessarily have a routine kidney checkup.

Munching on a chocolate bar or grabbing a pair of chips, the youngsters are unaware of getting trapped in a chronic syndrome.

Fatty liver is silently hitting the youth. It is no longer a disease confined to old age.

It is rapidly rising, affecting the majority of young girls and boys at the age of school or college.

The conundrum is that the condition remains silent.

The condition gradually reaches the advanced stages.

Know the fatty liver disorder – 

It is a chronic liver condition.

It starts from the accumulation of fat in the liver.

It can cause tissue scarring and advanced liver disorder.

The high amount of fat can cause inflammation.

It causes tissue injury.

What are the fatty liver types? 

Alcoholic Fatty Liver – 

Fatty liver is usually caused by alcohol.

Alcohol reduces fat metabolism.

It causes fat deposits in the liver.

Non Alcoholic Fatty Liver – 

The accumulation of fat in the liver is due to metabolic dysfunction.

The liver function gets impaired due to –

• Obesity
• Diabetes
• High lipids

Why is fatty liver disease happening more in the young? 

Lifestyle is the leading factor.

The prolonged hours of desk jobs combined with processed food.

Use of excessive salts and sugars.

Poor sleep habits combine to cause-

•  Metabolic dysfunction.
• Distorts glucose metabolism
• Disrupts fat breakdown

Fatty liver causes other than alcohol- 

Obesity/excess weight –  

The excess fat settles in the liver tissues.

It can lead to inflammation.

It often causes insulin resistance.

Poor diet – 

The high intake of processed food.

The extra calories get accumulated as fat.

The body is unable to metabolize glucose. It deposits in the form of fat.

Metabolic disorders – 

These interfere with insulin sensitivity.

Inhibits fat breakdown.

It causes excess fat production and its accumulation in the liver.

Physical inactivity- 

Due to reduced physical activity, the fat is not metabolized or burned.

The fat gets stored in the liver.

It leads to liver dysfunction.

Rapid weight loss diets- 

It overloads the liver to burn excessive fats.

It causes inflammation.

Fat breakdown causes fatty acid influx.

It can cause nutritional deficiency.

It causes the liver to work hard.

What are symptoms of fatty liver? 

At an early stage the fatty liver does not show symptoms.

It progresses to form advanced disease.

• Fatigue and weakness
• Abdominal pain
• Fluid retention
• Loss of appetite
• Unusual weight loss

The treatment and medicines used in fatty liver –

The fatty liver can be reversed by changing lifestyle and habits.

Improving diet and exercise can cause a reversal.

The advanced stages include the use of liver supportive medicines like –

Udikast 300 – Ursodeoxycholic acid tablets

Ocabest 10 – Obeticholic acid tablets

Aprazer Healthcare – Pioneering Liver Medicines 

Aprazer Healthcare is the leading pharmaceutical manufacturing company.

We are focused on manufacturing drugs targeting liver diseases and the underlying causes.

We have top-class R&D infrastructure.

Aprazer Healthcare is a major player in manufacturing advanced liver care medicines.

We specialize in manufacturing oncology treatment drugs for liver cancer.

We are the largest hepatology medicine manufacturer.

We manufacture drugs for chronic liver diseases like –

• Hepatitis B
• Hepatitis C
• Primary biliary cholangitis
• Fatty liver