How Manageable is HIV with Anti-Retroviral?
HIV has always been a menace to mankind, but the condition changes; knowing HIV is manageable, though not curable. The future of HIV treatments aims at managing HIV 100% and living a fulfilling life. Anti-retroviral therapies and combinations are increasing life expectancies and the quality of life.
How Does HIV Harm the Body?
- • Attacks CD4 cells
- • Damages CD4 cells
- • Down-regulates the immune system
It mimics the DNA and rapidly produces its cells, utilizing innate metabolic processes.
Step-by-Step Invasion by HIV
- • HIV binds to the surface of CD4 cells.
- • Fuses with the CD4 cell envelope and enters the CD4 cell.
- • Converts HIV RNA into HIV DNA.
- • Through the HIV integrase enzyme, it integrates its viral DNA into the CD4 cell DNA.
- • After integration, it replicates using CD4 DNA proteins to create viral RNA and proteins.
- • After producing copies, HIV steps out of the CD4 cells, damaging them and then infecting other CD4 cells.
Anti-Retroviral Therapy (ART)?
The combination of antiretroviral drugs:
- • Reduces the HIV load
- • Increases CD4 cell count
- • Restores the body’s immunity
CD4 cells are destroyed by HIV, weakening the immune system and making the body prone to opportunistic infections and negative health effects.
How Does Anti-Retroviral Work?
- Entry/Fusion Inhibitors: Inhibit membrane fusion and viral entry into CD4 cells.
- Reverse Transcriptase Inhibitors: They inhibit reverse transcriptase, thus block the conversion of RNA to DNA.
- Integrase Inhibitors: They inhibit the integrase enzyme from integrating Viral DNA into the CD4 DNA.
- Protease Inhibitors: Inhibit the protease enzyme and viral budding from the infected CD4 cells to invade another CD4 cell.
Primary Goals of ARVs?
- • To reduce the HIV count
- • To restore the immune system
- • Prolong survival
- • Reduce transmission
Why is it so Important to adhere to ARV Therapy?
HIV treatments mandate –lifelong antiretroviral regimen.
Adherence to HIV medicines –
- • Suppresses the virus
- • Reduces mutation capacity
- • Reduces drug resistance
Missing doses may increase the risk of –
- • Relapse
- • HIV mutations
- • Treatment failure and,
- • Transmission
Why is There a Need for Combination Drug Therapy?
The combination therapy blocks HIV multiplication at various stages, offers more protection, and potent effect.
The combination therapy also reduces drug resistance and is used for long-term effects.
The Potent Drug Combinations for Anti-retroviral Therapy?
- Virazer: Tenofovir Disoproxil Fumarate, Emtricitabine & Efavirenz
- Tudobest-L: Tenofovir Disoproxil Fumarate & Lamivudine
- Temirazer: Tenofovir Disoproxil Fumarate & Emtricitabine
- Tudobest-LE: Tenofovir Disoproxil Fumarate, Efavirenz & Lamivudine
Aprazer Healthcare leads the way in manufacturing premium quality HIV medicines with world-class manufacturing infrastructure.
